The factors of IgA Nephropathy we should know

IgA Nephropathy, also called Berger’s disease, is a kidney disorder that causes inflammation of the glomeruli, the filtering units of kidney that produce urine. IgA Nephropathy often occurs in the teen or early adult years. It affects more males than females. Well, what causes IgA Nephropathy. Follow us to learn the causes of IgA Nephropathy.

IgA Nephropathy can be primary IgA Nephropathy and secondary IgA Nephropathy. Primary IgA Nephropathy is a kind of disease of kidney itself, while secondary IgA Nephropathy is caused by other diseases such as HIV inflammation, Purpura Nephritis, liver disease, tumour and family IgA Nephropathy, etc.

No one knows what causes IgA Nephropathy clearly, but a majority of experts consider IgA Nephropathy is a glomeruli disease caused by the deposition of immune complexes.

Generally, the causes are related to the following three aspects.

1. Immune system disorder

IgA Nephropathy is manifested with IgA depositing in the glomeruli, which shows that IgA immune system leads to the occurrence of IgA in the circulation system and IgA deposition in the Glomeruli membrane area.

2. IgA Nephropathy is related to bone marrow.

The IgA deposition in the glomeruli membrane area is IgA deriving bone marrow.

3. Cytokines

The deposition of IgA1 in the glomeruli membrane area can lead to membrane cells to secrete inflammatory factors.

The inflammation is produced by the accumulation of a substance called immunoglobulin A (IgA) in the kidneys. IgA is a kind of antibody produced by the immune system. When your body fails to filter urine, it can’t excrete body wastes and excess fluid out of the bloodstream. IgA Nephropathy can lead to renal failure and other related complications.

Knowing the causes of IgA Nephropathy is helpful for you to take effective treatment to control IgA Nephropathy’s progression into renal failure.

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